Methotrax 2.5mg Tablet

✔️ Uses of Methotrax 2.5mg Tablet

• Choriocarcinoma
• Rheumatoid Arthritis
• Psoriasis
• Acute lymphoblastic Leukaemia (ALL) and Lymphoma

✔️ How does Methotrax 2.5mg Tablet work?

Methotrax 2.5mg Tablet stops or reduces inflammation in rheumatoid arthritis by altering the body’s defenses. In psoriasis, it kills the cells in the skin, which are growing too quickly. It is these fast-growing cells, which cause the raised patches of skin in psoriasis.

✔️ Side Effects of Methotrax 2.5mg Tablet

• Stomach discomfort
• Mouth ulcers
• Nausea
• Drowsiness
• Muscle pain

✔️ Quick Suggestions:

• Drink plenty of liquids to stay hydrated while taking this medication.
• Take folic acid if advised by your doctor. This will help lessen the side effects of this medicine.
• It may take from weeks to months for Mtx 2.5mg Tablet to work. Keep taking the medication as prescribed.
• Your doctor may get regular blood tests done to monitor your kidney function, liver function, and level of blood cells in your blood.
• Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
• It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.

✔️ Indications

Methotrax 10mg Tablet is used in the treatment of rheumatoid arthritis and psoriasis.

✔️ Pharmacology

Methotrax 10mg Tablet inhibits the enzyme dihydrofolic acid reductase. This enzyme is essential for converting dihydrofolates into tetrahydrofolates, which are necessary as carriers of one-carbon groups in the synthesis of nucleotides and thymidylate. By interfering with this process, Methotrax 10 mg disrupts DNA synthesis, repair, and cellular replication.

Tissues that actively proliferate, such as malignant cells, bone marrow, fetal cells, buccal and intestinal mucosa, and cells of the urinary bladder, are generally more sensitive to the effects of Methotrax 10 mg. When cellular proliferation in malignant tissues surpasses that of most normal tissues, Methotrax 10 mg may impede the growth of malignant cells without causing irreversible damage to normal tissues.

✔️ Dosage & Administration of Methotrax 2.5mg Tablet

Adult Dose:

Oral:

• Rheumatoid arthritis: 7.5 mg once weekly, adjust if needed (up to 20 mg/week).
• Crohn's disease: 12.5-22.5 mg once weekly for up to 1 year.
• Psoriasis: 10-25 mg once weekly, adjust subsequent doses if needed.

Child Dosage:

For Polyarticular Juvenile Idiopathic Arthritis:

• Initial dose: 10 mg/m² orally (PO) / intramuscularly (IM) / subcutaneously (SC) once a week.

For Meningeal Leukemia:

• Less than 1 year: 6 mg intrathecally (IT) every 2-5 days.
• 1-2 years: 8 mg IT every 2-5 days.
• 2-3 years: 10 mg IT every 2-5 days.
• Over 3 years: 12 mg IT every 2-5 days.

Renal Dose Adjustments:

In renal impairment based on creatinine clearance (CrCl):

• 61-80 ml/min: 75% of the usual dose.
• 51-60 ml/min: 70% of the usual dose.
• 10-50 ml/min: 30-50% of the usual dose.
• Less than 10 ml/min: Avoid use.

For intermittent hemodialysis:

• Administer 50% of the usual dose at the normal dosing interval.

For continuous renal replacement therapy:

• Administer 50% of the usual dose at the normal dosing interval.

The administration details for Methotrexate 2.5 MG Tablet are quite extensive. Here's a breakdown of the information:

Administration:

Oral (PO) Administration:

• Best taken on an empty stomach.
• May be taken with meals to reduce gastrointestinal discomfort.
• Avoid taking milk-rich products.

✔️ Interaction

Drug-Drug Interactions: Methotrax 2.5mg Tablet may interact with:

• Pain killers (celecoxib, acetaminophen, hydrocodone).
• Anti-depressant (duloxetine).
• Immunosuppressants (etanercept).
• Anti-rheumatoid (adalimumab).
• Antacid (esomeprazole).
• Anti-malarial (hydroxychloroquine).

Drug-Food Interactions: Avoid consuming alcohol while on treatment with Methotrax 2.5mg Tablet.

Drug-Disease Interactions: Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anemia, liver problems due to alcohol abuse, or chronic liver disease.

✔️ Do not take Methotrax 2.5mg Tablet if you:

• Are allergic to any of its components.
• Have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anemia, liver problems due to alcohol abuse, or chronic liver disease.
• Are pregnant or breastfeeding?

✔️ Pregnancy & Lactation

Pregnancy category X. Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

✔️ Talk to your doctor before taking Methotrax 2.5mg Tablet if you:

• Have or had liver or kidney problems.
• Have ulceration in the stomach or bowels.
• Are in poor general condition.
• Have received any vaccinations or are due to have any vaccinations?
• Have diabetes, ascites (fluid in the stomach area), lung problems, or fluid in the lungs.

Methotrax 2.5mg Tablet may cause dizziness and fatigue, so only drive if you are alert. Take it exactly as directed by the doctor, as it may lead to serious problems if not taken in the prescribed dose and duration. Stop taking Methotrax 2.5mg Tablet and consult your doctor immediately if you experience mouth sores, diarrhea, fever, dehydration, cough, bleeding, shortness of breath, signs of infection, or a skin rash.

✔️ Storage Conditions

Store below 30°C